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Index > Protein center > Slc2a8(Gene name) > Mouse
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  • Slc2a8 (Gene name),
  • Solute carrier family 2, facilitated glucose transporter member 8 (Protein name ),  GTR8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Slc2a8(Glut8;GlutX1);
    Protein name:
    Solute carrier family 2, facilitated glucose transporter member 8;
    Alternative:
    Glucose transporter type X1;Glucose transporter type 8(GLUT-8);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with AP2B1.
    Function:
    Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cytoplasmic vesicle membrane Multi-pass membrane protein Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane.
    Protein Attributes:
    Sequence length:
    477
    Sequence:
    50:
    MSPEDPQETQ | PLLRPPEART | PRGRRVFLAS | FAAALGPLSF | GFALGYSSPA | 
    100:
    IPSLRRTAPP | ALRLGDNAAS | WFGAVVTLGA | AAGGILGGWL | LDRAGRKLSL | 
    150:
    LLCTVPFVTG | FAVITAARDV | WMLLGGRLLT | GLACGVASLV | APVYISEIAY | 
    200:
    PAVRGLLGSC | VQLMVVTGIL | LAYVAGWVLE | WRWLAVLGCV | PPTLMLLLMC | 
    250:
    YMPETPRFLL | TQHQYQEAMA | ALRFLWGSEE | GWEEPPVGAE | HQGFQLALLR | 
    300:
    RPGIYKPLII | GISLMVFQQL | SGVNAIMFYA | NSIFEEAKFK | DSSLASVTVG | 
    350:
    IIQVLFTAVA | ALIMDRAGRR | LLLALSGVIM | VFSMSAFGTY | FKLTQSLPSN | 
    400:
    SSHVGLVPIA | AEPVDVQVGL | AWLAVGSMCL | FIAGFAVGWG | PIPWLLMSEI | 
    450:
    FPLHVKGVAT | GICVLTNWFM | AFLVTKEFSS | VMEMLRPYGA | FWLTAAFCAL | 
    477:
    SVLFTLTVVP | ETKGRTLEQV | TAHFEGR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Solute carrier family 2, facilitated glucose transporter member 8
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    ELISA Kit for Mouse Solute carrier family 2, facilitated glucose transporter member 8
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    CLIA Kit for Mouse Solute carrier family 2, facilitated glucose transporter member 8
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    U10948m
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    Packing:
    96T
    CLIA Kit for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Cat.:
    U10948h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Cat.:
    U10948b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Solute carrier family 2, facilitated glucose transporter member 8
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    U10948r
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    Polyclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Cat.:
    P10948Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Polyclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Cat.:
    P10948Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Cat.:
    P10948Rb-r
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Monoclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Monoclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Monoclonal Antibody for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Protein for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Protein for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Protein for Mouse Solute carrier family 2, facilitated glucose transporter member 8
    Protein for Mouse Solute carrier family 2, facilitated glucose transporter member 8

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    References
    1. 1.
      "GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues."
      Ibberson M.R. , Uldry M.A. , Thorens B.
      J. Biol. Chem.275:4607-4612(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity."
      Doege H. , Schuermann A. , Bahrenberg G. , Brauers A. , Joost H.-G.
      J. Biol. Chem.275:16275-16280(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    3. 3.
      "GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst."
      Carayannopoulos M.O. , Chi M.M.-Y. , Cui Y. , Pingsterhaus J.M. , McKnight R.A. , Mueckler M. , Devaskar S.U. , Moley K.H.
      Proc. Natl. Acad. Sci. U.S.A.97:7313-7318(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: 129.
      tissue: Embryonic carcinoma.
    4. 4.
      "Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose."
      Scheepers A. , Doege H. , Joost H.-G. , Schuermann A.
      Biochem. Biophys. Res. Commun.288:969-974(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/Ola.
      tissue: Spleen.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Head.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    7. 7.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Heart.
    9. 9.
      "Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex."
      Schmidt U. , Briese S. , Leicht K. , Schuermann A. , Joost H.-G. , Al-Hasani H.
      J. Cell Sci.119:2321-2331(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2B1;MUTAGENESIS OF 12-LEU-LEU-13
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